4cb8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_4cb8| PDB=4cb8 | SCENE= }}
+
==Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha==
-
===Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha===
+
<StructureSection load='4cb8' size='340' side='right' caption='[[4cb8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
{{ABSTRACT_PUBMED_24269683}}
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4cb8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CB8 FirstGlance]. <br>
-
==Function==
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cb9|4cb9]], [[4cba|4cba]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cb8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cb8 RCSB], [http://www.ebi.ac.uk/pdbsum/4cb8 PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
CTNNBL1 is a spliceosome-associated protein that binds nuclear localization signals (NLSs) in splice factors CDC5L and Prp31 as well as the antibody diversifying enzyme AID. Here, crystal structures of human CTNNBL1 reveal a distinct structure from its closest homologue karyopherin-alphas. CTNNBL1 comprises a HEAT-like domain (including a nuclear export signal), a central armadillo domain, and a coiled-coil C-terminal domain. Structure-guided mutations of the region homologous to the karyopherin-alpha NLS-binding site fail to disrupt CTNNBL1-NLS interactions. Our results identify CTNNBL1 as a unique selective NLS-binding protein with striking differences from karyopherin-alphas.
-
==About this Structure==
+
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha,Ganesh K, van Maldegem F, Telerman SB, Simpson P, Johnson CM, Williams RL, Neuberger MS, Rada C FEBS Lett. 2013 Nov 20. pii: S0014-5793(13)00847-8. doi:, 10.1016/j.febslet.2013.11.013. PMID:24269683<ref>PMID:24269683</ref>
-
[[4cb8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB8 OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:024269683</ref><references group="xtra"/><references/>
+
</div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Human]]
[[Category: Human]]
-
[[Category: Ganesh, K.]]
+
[[Category: Ganesh, K]]
-
[[Category: Johnson, C M.]]
+
[[Category: Johnson, C M]]
-
[[Category: Neuberger, M S.]]
+
[[Category: Neuberger, M S]]
-
[[Category: Rada, C.]]
+
[[Category: Rada, C]]
-
[[Category: Simpson, P.]]
+
[[Category: Simpson, P]]
-
[[Category: Telerman, S B.]]
+
[[Category: Telerman, S B]]
-
[[Category: Williams, R L.]]
+
[[Category: Williams, R L]]
-
[[Category: VanMaldegem, F.]]
+
[[Category: VanMaldegem, F]]
[[Category: Aid]]
[[Category: Aid]]
[[Category: Apoptosis]]
[[Category: Apoptosis]]
[[Category: Deaminase]]
[[Category: Deaminase]]
[[Category: Import]]
[[Category: Import]]

Revision as of 14:11, 25 December 2014

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha

4cb8, resolution 2.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4cb8"
Personal tools