2yeo
From Proteopedia
(Difference between revisions)
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<StructureSection load='2yeo' size='340' side='right' caption='[[2yeo]], [[Resolution|resolution]] 1.08Å' scene=''> | <StructureSection load='2yeo' size='340' side='right' caption='[[2yeo]], [[Resolution|resolution]] 1.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yeo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEO OCA]. <br> | + | <table><tr><td colspan='2'>[[2yeo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YEO FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DR0:N-(HYDROXYMETHYL)-N,N-DIMETHYLHEXAN-1-AMINIUM'>DR0</scene>, <scene name='pdbligand=DR8:N,N,N-TRIMETHYLHEPTA-1,3,5-TRIYN-1-AMINIUM'>DR8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DR0:N-(HYDROXYMETHYL)-N,N-DIMETHYLHEXAN-1-AMINIUM'>DR0</scene>, <scene name='pdbligand=DR8:N,N,N-TRIMETHYLHEPTA-1,3,5-TRIYN-1-AMINIUM'>DR8</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lqh|1lqh]], [[1lqi|1lqi]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lqh|1lqh]], [[1lqi|1lqi]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yeo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yeo RCSB], [http://www.ebi.ac.uk/pdbsum/2yeo PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/SCXA_LEIQH SCXA_LEIQH]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Leiurus quinquestriatus hebraeus]] | [[Category: Leiurus quinquestriatus hebraeus]] | ||
| - | [[Category: Frolow, F | + | [[Category: Frolow, F]] |
| - | [[Category: Gurevitz, M | + | [[Category: Gurevitz, M]] |
| - | [[Category: Kahn, R | + | [[Category: Kahn, R]] |
[[Category: Defense response]] | [[Category: Defense response]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 14:11, 25 December 2014
A39L MUTATION OF SCORPION TOXIN LQH-ALPHA-IT
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