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4nan
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4nan]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAN FirstGlance]. <br> | <table><tr><td colspan='2'>[[4nan]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NAN FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JM:2-BROMO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL'>2JM</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2JM:2-BROMO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL'>2JM</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w77|1w77]], [[2yc5|2yc5]], [[1ini|1ini]], [[4nai|4nai]], [[4nak|4nak]], [[4nal|4nal]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w77|1w77]], [[2yc5|2yc5]], [[1ini|1ini]], [[4nai|4nai]], [[4nak|4nak]], [[4nal|4nal]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At2g02500, ISPD, MCT, MECT, MEPCT, T8K22.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At2g02500, ISPD, MCT, MECT, MEPCT, T8K22.20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_4-phosphate_cytidylyltransferase 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.60 2.7.7.60] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nan RCSB], [http://www.ebi.ac.uk/pdbsum/4nan PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nan OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nan RCSB], [http://www.ebi.ac.uk/pdbsum/4nan PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ISPD_ARATH ISPD_ARATH]] Enzyme of the plastid non-mevalonate pathway for isoprenoid biosynthesis that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Is essential for chloroplast development and required for pigments and gibberellins biosynthesis.<ref>PMID:10841550</ref> <ref>PMID:12029484</ref> <ref>PMID:18236010</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.,Kunfermann A, Witschel M, Illarionov B, Martin R, Rottmann M, Hoffken HW, Seet M, Eisenreich W, Knolker HJ, Fischer M, Bacher A, Groll M, Diederich F Angew Chem Int Ed Engl. 2014 Jan 20. doi: 10.1002/anie.201309557. PMID:24446431<ref>PMID:24446431</ref> | Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD.,Kunfermann A, Witschel M, Illarionov B, Martin R, Rottmann M, Hoffken HW, Seet M, Eisenreich W, Knolker HJ, Fischer M, Bacher A, Groll M, Diederich F Angew Chem Int Ed Engl. 2014 Jan 20. doi: 10.1002/anie.201309557. PMID:24446431<ref>PMID:24446431</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[MEP cytidylyltransferase|MEP cytidylyltransferase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 23: | Line 28: | ||
[[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]] | [[Category: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase]] | ||
[[Category: Arath]] | [[Category: Arath]] | ||
| - | [[Category: Bacher, A | + | [[Category: Bacher, A]] |
| - | [[Category: Diederich, F | + | [[Category: Diederich, F]] |
| - | [[Category: Eisenreich, W | + | [[Category: Eisenreich, W]] |
| - | [[Category: Fischer, M | + | [[Category: Fischer, M]] |
| - | [[Category: Groll, M | + | [[Category: Groll, M]] |
| - | [[Category: Hoffken, H W | + | [[Category: Hoffken, H W]] |
| - | [[Category: Illarionov, B | + | [[Category: Illarionov, B]] |
| - | [[Category: Knolker, H J | + | [[Category: Knolker, H J]] |
| - | [[Category: Kunfermann, A | + | [[Category: Kunfermann, A]] |
| - | [[Category: Martin, R | + | [[Category: Martin, R]] |
| - | [[Category: Rottmann, M | + | [[Category: Rottmann, M]] |
| - | [[Category: Seet, M | + | [[Category: Seet, M]] |
| - | [[Category: Witschel, M | + | [[Category: Witschel, M]] |
[[Category: Allosteric inhibition]] | [[Category: Allosteric inhibition]] | ||
[[Category: Anti-infective]] | [[Category: Anti-infective]] | ||
Revision as of 14:15, 25 December 2014
Arabidopsis thaliana IspD in complex with tetrabromo-pseudilin
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Categories: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase | Arath | Bacher, A | Diederich, F | Eisenreich, W | Fischer, M | Groll, M | Hoffken, H W | Illarionov, B | Knolker, H J | Kunfermann, A | Martin, R | Rottmann, M | Seet, M | Witschel, M | Allosteric inhibition | Anti-infective | Drug discovery | Herbicide | Natural product | Pseudilin | Rossmann fold | Transferase | Transferase-transferase inhibitor complex
