4fts
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fts OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fts RCSB], [http://www.ebi.ac.uk/pdbsum/4fts PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fts OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fts RCSB], [http://www.ebi.ac.uk/pdbsum/4fts PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV]] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable). | ||
==See Also== | ==See Also== | ||
Revision as of 14:19, 25 December 2014
Crystal structure of the N363T mutant of the Flock House virus capsid
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