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3qr5
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qr5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qr5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qr5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qr5 RCSB], [http://www.ebi.ac.uk/pdbsum/3qr5 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9ERN6_MOUSE Q9ERN6_MOUSE]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 14:21, 25 December 2014
Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 deleted
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