2m85

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{{STRUCTURE_2m85| PDB=2m85 | SCENE= }}
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==PHD Domain from Human SHPRH==
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===PHD Domain from Human SHPRH===
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<StructureSection load='2m85' size='340' side='right' caption='[[2m85]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[2m85]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M85 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fui|2fui]], [[1xwh|1xwh]], [[1wep|1wep]], [[2jmi|2jmi]], [[2vpd|2vpd]], [[2rsd|2rsd]], [[1x4i|1x4i]], [[2k16|2k16]], [[2k1j|2k1j]], [[2kkg|2kkg]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SHPRH, KIAA2023 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m85 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m85 RCSB], [http://www.ebi.ac.uk/pdbsum/2m85 PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN]] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref>
[[http://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN]] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref>
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==About this Structure==
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==See Also==
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[[2m85]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M85 OCA].
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*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023907177</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Almeida, F C.L.]]
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[[Category: Almeida, F C.L]]
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[[Category: Bezsonova, I.]]
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[[Category: Bezsonova, I]]
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[[Category: Korzhnev, D M.]]
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[[Category: Korzhnev, D M]]
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[[Category: Machado, L E.S F.]]
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[[Category: Machado, L E.S F]]
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[[Category: Pozhidaeva, A.]]
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[[Category: Pozhidaeva, A]]
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[[Category: Pustovalova, Y.]]
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[[Category: Pustovalova, Y]]
[[Category: Helicase]]
[[Category: Helicase]]
[[Category: Histone linker]]
[[Category: Histone linker]]

Revision as of 14:34, 25 December 2014

PHD Domain from Human SHPRH

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