3rjr

From Proteopedia

(Difference between revisions)

Revision as of 14:35, 25 December 2014

Crystal Structure of pro-TGF beta 1

Structural highlights

3rjr is a 4 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	TGFB1 (Sus scrofa)
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[TGFB1_PIG] Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity).

Publication Abstract from PubMed

Transforming growth factor (TGF)-beta is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-beta1 requires the binding of alpha(v) integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-beta binding proteins. Crystals of dimeric porcine proTGF-beta1 reveal a ring-shaped complex, a novel fold for the prodomain, and show how the prodomain shields the growth factor from recognition by receptors and alters its conformation. Complex formation between alpha(v)beta(6) integrin and the prodomain is insufficient for TGF-beta1 release. Force-dependent activation requires unfastening of a 'straitjacket' that encircles each growth-factor monomer at a position that can be locked by a disulphide bond. Sequences of all 33 TGF-beta family members indicate a similar prodomain fold. The structure provides insights into the regulation of a family of growth and differentiation factors of fundamental importance in morphogenesis and homeostasis.

Latent TGF-beta structure and activation.,Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA Nature. 2011 Jun 15;474(7351):343-9. doi: 10.1038/nature10152. PMID:21677751^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA. Latent TGF-beta structure and activation. Nature. 2011 Jun 15;474(7351):343-9. doi: 10.1038/nature10152. PMID:21677751 doi:http://dx.doi.org/10.1038/nature10152

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3rjr"

@@ Line 7: / Line 7: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rjr RCSB], [http://www.ebi.ac.uk/pdbsum/3rjr PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TGFB1_PIG TGFB1_PIG]] Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==

3rjr

From Proteopedia

Revision as of 14:35, 25 December 2014

Crystal Structure of pro-TGF beta 1

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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