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3ixx
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ixx]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXX FirstGlance]. <br> | <table><tr><td colspan='2'>[[3ixx]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/West_nile_virus West nile virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXX FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixx RCSB], [http://www.ebi.ac.uk/pdbsum/3ixx PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixx RCSB], [http://www.ebi.ac.uk/pdbsum/3ixx PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9Q6P4_WNV Q9Q6P4_WNV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS011998_004_099774] [[http://www.uniprot.org/uniprot/Q9WHD2_WNV Q9WHD2_WNV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: West nile virus]] | [[Category: West nile virus]] | ||
| - | [[Category: Cherrier, M V | + | [[Category: Cherrier, M V]] |
| - | [[Category: Chipman, P R | + | [[Category: Chipman, P R]] |
| - | [[Category: Diamond, M S | + | [[Category: Diamond, M S]] |
| - | [[Category: Fremont, D H | + | [[Category: Fremont, D H]] |
| - | [[Category: Holdaway, H A | + | [[Category: Holdaway, H A]] |
| - | [[Category: Kaufmann, B | + | [[Category: Kaufmann, B]] |
| - | [[Category: Kostyuchenko, V A | + | [[Category: Kostyuchenko, V A]] |
| - | [[Category: Kuhn, R J | + | [[Category: Kuhn, R J]] |
| - | [[Category: Lok, S M | + | [[Category: Lok, S M]] |
| - | [[Category: Nelson, C A | + | [[Category: Nelson, C A]] |
| - | [[Category: Nybakken, G E | + | [[Category: Nybakken, G E]] |
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
| - | [[Category: Warren, J T | + | [[Category: Warren, J T]] |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: E53]] | [[Category: E53]] | ||
| Line 60: | Line 62: | ||
[[Category: Virion]] | [[Category: Virion]] | ||
[[Category: Virus]] | [[Category: Virus]] | ||
| - | [[Category: West nile virus]] | ||
[[Category: Wnv]] | [[Category: Wnv]] | ||
Revision as of 14:35, 25 December 2014
The pseudo-atomic structure of West Nile immature virus in complex with Fab fragments of the anti-fusion loop antibody E53
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Categories: Mus musculus | West nile virus | Cherrier, M V | Chipman, P R | Diamond, M S | Fremont, D H | Holdaway, H A | Kaufmann, B | Kostyuchenko, V A | Kuhn, R J | Lok, S M | Nelson, C A | Nybakken, G E | Rossmann, M G | Warren, J T | Atp-binding | E53 | Envelope protein | Fab | Fusion loop | Helicase | Hydrolase | Icosahedral virus | Immature | Membrane | Nucleotide-binding | Rna replication | Transmembrane | Virion | Virus | Wnv
