2duv

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[[Image:2duv.jpg|left|200px]]<br /><applet load="2duv" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2duv.jpg|left|200px]]
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caption="2duv, resolution 2.2&Aring;" />
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'''Structure of CDK2 with a 3-hydroxychromones'''<br />
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{{Structure
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|PDB= 2duv |SIZE=350|CAPTION= <scene name='initialview01'>2duv</scene>, resolution 2.2&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=371:2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE'>371</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22]
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|GENE=
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}}
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'''Structure of CDK2 with a 3-hydroxychromones'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2DUV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=371:'>371</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUV OCA].
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2DUV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUV OCA].
==Reference==
==Reference==
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3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17178224 17178224]
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3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17178224 17178224]
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: serine/threonine-protein kinase]]
[[Category: serine/threonine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:02:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:31:54 2008''

Revision as of 14:31, 20 March 2008

Image:2duv.jpg


PDB ID 2duv

Drag the structure with the mouse to rotate
, resolution 2.2Å
Ligands:
Activity: Cyclin-dependent kinase, with EC number 2.7.11.22
Coordinates: save as pdb, mmCIF, xml



Structure of CDK2 with a 3-hydroxychromones


Overview

A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

About this Structure

2DUV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:17178224

Page seeded by OCA on Thu Mar 20 16:31:54 2008

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