1jr1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1jr1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JR1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOA:MYCOPHENOLIC+ACID'>MOA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ak5|1ak5]], [[1b3o|1b3o]], [[1zfj|1zfj]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ak5|1ak5]], [[1b3o|1b3o]], [[1zfj|1zfj]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jr1 RCSB], [http://www.ebi.ac.uk/pdbsum/1jr1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IMDH2_CRIGR IMDH2_CRIGR]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (By similarity). It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Cricetulus griseus]] | [[Category: Cricetulus griseus]] | ||
[[Category: IMP dehydrogenase]] | [[Category: IMP dehydrogenase]] | ||
| - | [[Category: Caron, P R | + | [[Category: Caron, P R]] |
| - | [[Category: Chambers, S P | + | [[Category: Chambers, S P]] |
| - | [[Category: Fleming, M A | + | [[Category: Fleming, M A]] |
| - | [[Category: Futer, O | + | [[Category: Futer, O]] |
| - | [[Category: Murcko, M A | + | [[Category: Murcko, M A]] |
| - | [[Category: Raybuck, S A | + | [[Category: Raybuck, S A]] |
| - | [[Category: Sintchak, M D | + | [[Category: Sintchak, M D]] |
| - | [[Category: Wilson, K P | + | [[Category: Wilson, K P]] |
[[Category: Dehydrogenase]] | [[Category: Dehydrogenase]] | ||
[[Category: Guanine nucleotide synthesis]] | [[Category: Guanine nucleotide synthesis]] | ||
Revision as of 14:41, 25 December 2014
Crystal structure of Inosine Monophosphate Dehydrogenase in complex with Mycophenolic Acid
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