2f5y

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[2f5y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F5Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2F5Y FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1i92|1i92]], [[1qau|1qau]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1i92|1i92]], [[1qau|1qau]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RGS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5y RCSB], [http://www.ebi.ac.uk/pdbsum/2f5y PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f5y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2f5y RCSB], [http://www.ebi.ac.uk/pdbsum/2f5y PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RGS3_HUMAN RGS3_HUMAN]] Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.<ref>PMID:8602223</ref> <ref>PMID:9858594</ref> <ref>PMID:10749886</ref> <ref>PMID:11294858</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith, C]]
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[[Category: Berridge, G.]]
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[[Category: Berridge, G]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi, G]]
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[[Category: Burgess, N.]]
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[[Category: Burgess, N]]
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[[Category: Colebrook, S.]]
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[[Category: Colebrook, S]]
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[[Category: Debreczeni, J.]]
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[[Category: Debreczeni, J]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Doyle, D.]]
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[[Category: Doyle, D]]
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[[Category: Edwards, A.]]
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[[Category: Edwards, A]]
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[[Category: Elkins, J.]]
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[[Category: Elkins, J]]
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[[Category: Gorrec, F.]]
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[[Category: Gorrec, F]]
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[[Category: Johansson, C.]]
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[[Category: Johansson, C]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Papagrigoriou, E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Savitsky, P.]]
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[[Category: Savitsky, P]]
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[[Category: Smee, C.]]
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[[Category: Smee, C]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom, M]]
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[[Category: Turnbull, A.]]
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[[Category: Turnbull, A]]
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[[Category: Ugochukwu, E.]]
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[[Category: Ugochukwu, E]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
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[[Category: Yang, X.]]
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[[Category: Yang, X]]
[[Category: Human]]
[[Category: Human]]
[[Category: Pdz domain]]
[[Category: Pdz domain]]
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[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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[[Category: Structural genomic]]
 
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[[Category: Structural genomics consortium]]
 

Revision as of 14:50, 25 December 2014

Crystal Structure of the PDZ Domain from Human RGS-3

2f5y, resolution 2.39Å

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