1hoy
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1hoy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HOY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HOY FirstGlance]. <br> | <table><tr><td colspan='2'>[[1hoy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HOY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HOY FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hn7|1hn7]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hn7|1hn7]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hoy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hoy RCSB], [http://www.ebi.ac.uk/pdbsum/1hoy PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hoy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hoy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hoy RCSB], [http://www.ebi.ac.uk/pdbsum/1hoy PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NXL1A_BUNMU NXL1A_BUNMU]] Binds with high affinity to muscular and neuronal (alpha-7, alpha-8, and alpha-9) nicotinic acetylcholine receptors. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 uM).<ref>PMID:9305882</ref> <ref>PMID:9840221</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bungarus multicinctus]] | [[Category: Bungarus multicinctus]] | ||
| - | [[Category: Bernini, A | + | [[Category: Bernini, A]] |
| - | [[Category: Bracci, L | + | [[Category: Bracci, L]] |
| - | [[Category: Calamandrei, D | + | [[Category: Calamandrei, D]] |
| - | [[Category: Ciutti, A | + | [[Category: Ciutti, A]] |
| - | [[Category: Lelli, B | + | [[Category: Lelli, B]] |
| - | [[Category: Lozzi, L | + | [[Category: Lozzi, L]] |
| - | [[Category: Maro, D Di | + | [[Category: Maro, D Di]] |
| - | [[Category: Neri, P | + | [[Category: Neri, P]] |
| - | [[Category: Niccolai, N | + | [[Category: Niccolai, N]] |
| - | [[Category: Scarselli, M | + | [[Category: Scarselli, M]] |
| - | [[Category: Spiga, O | + | [[Category: Spiga, O]] |
[[Category: Acchor mimotope]] | [[Category: Acchor mimotope]] | ||
[[Category: Alpha-bungarotoxin]] | [[Category: Alpha-bungarotoxin]] | ||
Revision as of 14:54, 25 December 2014
NMR STRUCTURE OF THE COMPLEX BETWEEN A-BUNGAROTOXIN AND A MIMOTOPE OF THE NICOTINIC ACETYLCHOLINE RECEPTOR
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