2mll
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLL FirstGlance]. <br> | <table><tr><td colspan='2'>[[2mll]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MLL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mll RCSB], [http://www.ebi.ac.uk/pdbsum/2mll PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mll OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mll RCSB], [http://www.ebi.ac.uk/pdbsum/2mll PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MLB1_VISAL MLB1_VISAL]] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Viscum album]] | [[Category: Viscum album]] | ||
| - | [[Category: Betzel, C | + | [[Category: Betzel, C]] |
| - | [[Category: Eschenburg, S | + | [[Category: Eschenburg, S]] |
| - | [[Category: Konareva, N | + | [[Category: Konareva, N]] |
| - | [[Category: Kornilov, V | + | [[Category: Kornilov, V]] |
| - | [[Category: Krauspenhaar, R | + | [[Category: Krauspenhaar, R]] |
| - | [[Category: Maier, T | + | [[Category: Maier, T]] |
| - | [[Category: Mikailova, I | + | [[Category: Mikailova, I]] |
| - | [[Category: Mikhailov, A | + | [[Category: Mikhailov, A]] |
| - | [[Category: Perbandt, M | + | [[Category: Perbandt, M]] |
| - | [[Category: Singh, T P | + | [[Category: Singh, T P]] |
| - | [[Category: Stoeva, S | + | [[Category: Stoeva, S]] |
| - | [[Category: Voelter, W | + | [[Category: Voelter, W]] |
| - | [[Category: Wacker, R | + | [[Category: Wacker, R]] |
[[Category: Ribosome]] | [[Category: Ribosome]] | ||
[[Category: Ribosome-inactivating protein type ii]] | [[Category: Ribosome-inactivating protein type ii]] | ||
Revision as of 14:55, 25 December 2014
MISTLETOE LECTIN I FROM VISCUM ALBUM
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