2o6h

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2o6h]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_melitensis Brucella melitensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O6H FirstGlance]. <br>
<table><tr><td colspan='2'>[[2o6h]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Brucella_melitensis Brucella melitensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O6H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O6H FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=INI:5-NITRO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE'>INI</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=INI:5-NITRO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE'>INI</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f59|2f59]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f59|2f59]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ribH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29459 Brucella melitensis])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ribH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29459 Brucella melitensis])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o6h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o6h RCSB], [http://www.ebi.ac.uk/pdbsum/2o6h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o6h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o6h RCSB], [http://www.ebi.ac.uk/pdbsum/2o6h PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RISB1_BRUME RISB1_BRUME]] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:17854827</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
[[Category: Brucella melitensis]]
[[Category: Brucella melitensis]]
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[[Category: Bacher, A.]]
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[[Category: Bacher, A]]
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[[Category: Bonomi, H R.]]
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[[Category: Bonomi, H R]]
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[[Category: Braden, B C.]]
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[[Category: Braden, B C]]
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[[Category: Fischer, M.]]
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[[Category: Fischer, M]]
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[[Category: Goldbaum, F A.]]
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[[Category: Goldbaum, F A]]
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[[Category: Guimaraes, B G.]]
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[[Category: Guimaraes, B G]]
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[[Category: Haase, I.]]
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[[Category: Haase, I]]
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[[Category: Klinke, S.]]
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[[Category: Klinke, S]]
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[[Category: Zylberman, V.]]
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[[Category: Zylberman, V]]
[[Category: Lumazine synthase]]
[[Category: Lumazine synthase]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 14:56, 25 December 2014

Lumazine synthase RibH1 from Brucella melitensis (Gene BMEI1187, Swiss-Prot entry Q8YGH2) complexed with inhibitor 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione

2o6h, resolution 2.70Å

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