2hw5
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hw5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HW5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2hw5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HW5 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECHS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECHS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hw5 RCSB], [http://www.ebi.ac.uk/pdbsum/2hw5 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hw5 RCSB], [http://www.ebi.ac.uk/pdbsum/2hw5 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ECHM_HUMAN ECHM_HUMAN]] Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Enoyl-CoA hydratase]] | [[Category: Enoyl-CoA hydratase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C | + | [[Category: Arrowsmith, C]] |
| - | [[Category: Debreczeni, J | + | [[Category: Debreczeni, J]] |
| - | [[Category: Delft, F von | + | [[Category: Delft, F von]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Gileadi, O | + | [[Category: Gileadi, O]] |
| - | [[Category: Gorrec, F | + | [[Category: Gorrec, F]] |
| - | [[Category: Kavanagh, K | + | [[Category: Kavanagh, K]] |
| - | [[Category: Niesen, F | + | [[Category: Niesen, F]] |
| - | [[Category: Oppermann, U | + | [[Category: Oppermann, U]] |
| - | [[Category: Pike, A C.W | + | [[Category: Pike, A C.W]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Salah, E | + | [[Category: Salah, E]] |
| - | [[Category: Sundstrom, M | + | [[Category: Sundstrom, M]] |
| - | [[Category: Turnbull, A P | + | [[Category: Turnbull, A P]] |
| - | [[Category: Ugochukwu, E | + | [[Category: Ugochukwu, E]] |
| - | [[Category: Umeano, C | + | [[Category: Umeano, C]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
[[Category: Beta-oxidation]] | [[Category: Beta-oxidation]] | ||
[[Category: Coa]] | [[Category: Coa]] | ||
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[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Revision as of 14:57, 25 December 2014
The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1
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Categories: Enoyl-CoA hydratase | Homo sapiens | Arrowsmith, C | Debreczeni, J | Delft, F von | Edwards, A | Gileadi, O | Gorrec, F | Kavanagh, K | Niesen, F | Oppermann, U | Pike, A C.W | Structural genomic | Salah, E | Sundstrom, M | Turnbull, A P | Ugochukwu, E | Umeano, C | Weigelt, J | Beta-oxidation | Coa | Enoyl-coa hydratase | Fatty acid metabolism | Hydratase/isomerase superfamily | Lyase | Sgc
