2dz7

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[[Image:2dz7.jpg|left|200px]]<br /><applet load="2dz7" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2dz7.jpg|left|200px]]
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caption="2dz7, resolution 1.60&Aring;" />
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'''DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)'''<br />
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{{Structure
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|PDB= 2dz7 |SIZE=350|CAPTION= <scene name='initialview01'>2dz7</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2DZ7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZ7 OCA].
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2DZ7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZ7 OCA].
==Reference==
==Reference==
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DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17062599 17062599]
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DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17062599 17062599]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Kondo, J.]]
[[Category: Kondo, J.]]
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[[Category: vntr]]
[[Category: vntr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:04:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:33:19 2008''

Revision as of 14:33, 20 March 2008

Image:2dz7.jpg


PDB ID 2dz7

Drag the structure with the mouse to rotate
, resolution 1.60Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)


Overview

The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.

About this Structure

2DZ7 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599

Page seeded by OCA on Thu Mar 20 16:33:19 2008

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