4rf1
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rf1 RCSB], [http://www.ebi.ac.uk/pdbsum/4rf1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rf1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rf1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rf1 RCSB], [http://www.ebi.ac.uk/pdbsum/4rf1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RL40_HUMAN RL40_HUMAN]] Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref> Ribosomal protein L40 is a component of the 60S subunit of the ribosome.<ref>PMID:16543144</ref> <ref>PMID:19754430</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Bailey-Elkin, B A | + | [[Category: Bailey-Elkin, B A]] |
| - | [[Category: Johnson, G G | + | [[Category: Johnson, G G]] |
| - | [[Category: Mark, B L | + | [[Category: Mark, B L]] |
[[Category: Deubiquitinase]] | [[Category: Deubiquitinase]] | ||
[[Category: Papain-like protease]] | [[Category: Papain-like protease]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Zinc ribbon]] | [[Category: Zinc ribbon]] | ||
Revision as of 15:06, 25 December 2014
Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P63)
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