2dzd
From Proteopedia
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| - | [[Image:2dzd.jpg|left|200px]] | + | [[Image:2dzd.jpg|left|200px]] |
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| - | '''Crystal structure of the biotin carboxylase domain of pyruvate carboxylase''' | + | {{Structure |
| + | |PDB= 2dzd |SIZE=350|CAPTION= <scene name='initialview01'>2dzd</scene>, resolution 2.4Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Pyruvate_carboxylase Pyruvate carboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.4.1.1 6.4.1.1] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the biotin carboxylase domain of pyruvate carboxylase''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2DZD is a [ | + | 2DZD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_thermodenitrificans Geobacillus thermodenitrificans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DZD OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the biotin carboxylase domain of pyruvate carboxylase from Bacillus thermodenitrificans., Kondo S, Nakajima Y, Sugio S, Sueda S, Islam MN, Kondo H, Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):885-90. Epub 2007, Jul 17. PMID:[http:// | + | Structure of the biotin carboxylase domain of pyruvate carboxylase from Bacillus thermodenitrificans., Kondo S, Nakajima Y, Sugio S, Sueda S, Islam MN, Kondo H, Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):885-90. Epub 2007, Jul 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17642515 17642515] |
[[Category: Geobacillus thermodenitrificans]] | [[Category: Geobacillus thermodenitrificans]] | ||
[[Category: Pyruvate carboxylase]] | [[Category: Pyruvate carboxylase]] | ||
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[[Category: Sueda, S.]] | [[Category: Sueda, S.]] | ||
[[Category: Sugio, S.]] | [[Category: Sugio, S.]] | ||
| - | [[Category: bacillus | + | [[Category: bacillus thermodenitrifican]] |
[[Category: biotin carboxylase]] | [[Category: biotin carboxylase]] | ||
[[Category: ligase]] | [[Category: ligase]] | ||
[[Category: pyruvate carboxylase]] | [[Category: pyruvate carboxylase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:33:23 2008'' |
Revision as of 14:33, 20 March 2008
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| , resolution 2.4Å | |||||||
|---|---|---|---|---|---|---|---|
| Activity: | Pyruvate carboxylase, with EC number 6.4.1.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the biotin carboxylase domain of pyruvate carboxylase
Overview
The biotin carboxylase (BC) domain of pyruvate carboxylase (PC) from Bacillus thermodenitrificans (BC-bPC) was crystallized in an orthorhombic form (space group P2(1)2(1)2(1)), with unit-cell parameters a = 79.6, b = 116.0, c = 115.7 A. Two BC protomers are contained in the asymmetric unit. Diffraction data were collected at 100 K and the crystal structure was solved by the molecular-replacement method and refined against reflections in the 20.0-2.4 A resolution range, giving an R factor of 0.235 and a free R factor of 0.292. The overall structure of BC-bPC is similar to those of the BC subunits of Aquifex aeolicus PC (BC-aPC) and Escherichia coli ACC (BC-eACC). The crystal structure revealed that BC-bPC forms a unique dimeric quaternary structure, which might be caused as a result of the division of the BC domain from the rest of the protein. The position of domain B in BC-bPC differs from those in other enzymes of similar structure (BC-aPC and BC-eACC).
About this Structure
2DZD is a Single protein structure of sequence from Geobacillus thermodenitrificans. Full crystallographic information is available from OCA.
Reference
Structure of the biotin carboxylase domain of pyruvate carboxylase from Bacillus thermodenitrificans., Kondo S, Nakajima Y, Sugio S, Sueda S, Islam MN, Kondo H, Acta Crystallogr D Biol Crystallogr. 2007 Aug;63(Pt 8):885-90. Epub 2007, Jul 17. PMID:17642515
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