This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3tz0
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex== | |
| - | + | <StructureSection load='3tz0' size='340' side='right' caption='[[3tz0]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[3tz0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TZ0 FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03H:(2S)-2-CHLORO-4-METHYLPENTANOIC+ACID'>03H</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tz2|3tz2]], [[3tz4|3tz4]], [[3tz5|3tz5]], [[4dzy|4dzy]], [[4h7q|4h7q]], [[4h81|4h81]], [[4h85|4h85]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Bckdk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[3-methyl-2-oxobutanoate_dehydrogenase_(acetyl-transferring)]_kinase [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.4 2.7.11.4] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tz0 RCSB], [http://www.ebi.ac.uk/pdbsum/3tz0 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. | [[http://www.uniprot.org/uniprot/BCKD_RAT BCKD_RAT]] Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Chuang, D T | + | [[Category: Chuang, D T]] |
| - | [[Category: Chuang, J L | + | [[Category: Chuang, J L]] |
| - | [[Category: Gui, W J | + | [[Category: Gui, W J]] |
| - | [[Category: Li, J | + | [[Category: Li, J]] |
| - | [[Category: Tso, S C | + | [[Category: Tso, S C]] |
| - | [[Category: Wynn, R M | + | [[Category: Wynn, R M]] |
[[Category: Allosteric kinase inhibitor]] | [[Category: Allosteric kinase inhibitor]] | ||
[[Category: Bergerat nucleotide-binding fold]] | [[Category: Bergerat nucleotide-binding fold]] | ||
Revision as of 15:10, 25 December 2014
Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex
| |||||||||||
Categories: Rattus norvegicus | Chuang, D T | Chuang, J L | Gui, W J | Li, J | Tso, S C | Wynn, R M | Allosteric kinase inhibitor | Bergerat nucleotide-binding fold | Branched-chain alpha-ketoacid | Branched-chain amino acid | Diabetes and obesity | Ghkl protein kinase | Maple syrup urine disease | Protein kinase | Transferase-transferase inhibitor complex
