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2ci8
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ci8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CI8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ci8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CI8 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cub|2cub]], [[2ci9|2ci9]], [[2cia|2cia]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cub|2cub]], [[2ci9|2ci9]], [[2cia|2cia]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ci8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ci8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ci8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ci8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ci8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ci8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ci8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ci8 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Findeis, A C | + | [[Category: Findeis, A C]] |
| - | [[Category: Frese, S | + | [[Category: Frese, S]] |
| - | [[Category: Heinz, D W | + | [[Category: Heinz, D W]] |
| - | [[Category: Marquardt, T | + | [[Category: Marquardt, T]] |
| - | [[Category: Roske, Y S | + | [[Category: Roske, Y S]] |
| - | [[Category: Schubert, W D | + | [[Category: Schubert, W D]] |
| - | [[Category: Stradal, T E.B | + | [[Category: Stradal, T E.B]] |
[[Category: Binding specificity]] | [[Category: Binding specificity]] | ||
[[Category: Host-pathogen]] | [[Category: Host-pathogen]] | ||
[[Category: Interaction]] | [[Category: Interaction]] | ||
[[Category: Translation]] | [[Category: Translation]] | ||
Revision as of 15:19, 25 December 2014
SH2 DOMAIN OF HUMAN NCK1 ADAPTOR PROTEIN - UNCOMPLEXED
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