1id1

From Proteopedia

(Difference between revisions)

Revision as of 15:23, 25 December 2014

CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL

Structural highlights

1id1 is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[KCH_ECOLI] K(+)-specific ion channel. May play a role in the defense against osmotic shock.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K+ transporters and K+ channels. The RCK domain has a Rossmann-fold topology with unique positions, not commonly conserved among Rossmann-fold proteins, composing a well-conserved salt bridge and a hydrophobic dimer interface. Structure-based amino acid sequence alignments and mutational analysis are used to demonstrate that an RCK domain is also present and is an important component of the gating machinery in eukaryotic large-conductance Ca2+ activated K+ channels.

Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel.,Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R Neuron. 2001 Mar;29(3):593-601. PMID:11301020^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Milkman R. An Escherichia coli homologue of eukaryotic potassium channel proteins. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3510-4. PMID:8170937
↑ Kuo MM, Saimi Y, Kung C. Gain-of-function mutations indicate that Escherichia coli Kch forms a functional K+ conduit in vivo. EMBO J. 2003 Aug 15;22(16):4049-58. PMID:12912904 doi:http://dx.doi.org/10.1093/emboj/cdg409
↑ Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron. 2001 Mar;29(3):593-601. PMID:11301020

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1id1"

@@ Line 3: / Line 3: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1id1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ID1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ID1 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1id1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1id1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1id1 RCSB], [http://www.ebi.ac.uk/pdbsum/1id1 PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1id1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1id1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1id1 RCSB], [http://www.ebi.ac.uk/pdbsum/1id1 PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/KCH_ECOLI KCH_ECOLI]] K(+)-specific ion channel. May play a role in the defense against osmotic shock.<ref>PMID:8170937</ref> <ref>PMID:12912904</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 28: / Line 30: @@
 </StructureSection>
 [[Category: Escherichia coli]]
-[[Category: Cadene, M.]]
+[[Category: Cadene, M]]
-[[Category: Chait, B T.]]
+[[Category: Chait, B T]]
-[[Category: Jiang, Y.]]
+[[Category: Jiang, Y]]
-[[Category: MacKinnon, R.]]
+[[Category: MacKinnon, R]]
-[[Category: Pico, A.]]
+[[Category: Pico, A]]
 [[Category: Bk channel]]
 [[Category: E coli potassium channel]]

1id1

From Proteopedia

Revision as of 15:23, 25 December 2014

CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox