1pv0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1pv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PV0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1pv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PV0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sda ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sda ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1pv0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1pv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1pv0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SDA_BACSU SDA_BACSU]] Mediates a developmental checkpoint inhibiting initiation of sporulation (by preventing phosphorylation of spo0A) in response to defects in the replication initiation machinery. Inhibits autophosphorylation of the histidine protein kinase KinA, forming a molecular barricade that prevents productive interaction between the ATP-binding site in the catalytic domain and the phosphorylatable His in the phosphotransfer domain of KinA. Probably also inhibits the activity of KinB, but has relatively little effect on KinC. Has at least one target in vivo in addition to KinA as sda does not require KinA to inhibit sporulation.<ref>PMID:11207367</ref> <ref>PMID:15023339</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
| - | [[Category: Burkholder, W F | + | [[Category: Burkholder, W F]] |
| - | [[Category: Grossman, A D | + | [[Category: Grossman, A D]] |
| - | [[Category: King, G F | + | [[Category: King, G F]] |
| - | [[Category: Maciejewski, M W | + | [[Category: Maciejewski, M W]] |
| - | [[Category: Rowland, S L | + | [[Category: Rowland, S L]] |
[[Category: Antikinase]] | [[Category: Antikinase]] | ||
[[Category: Histidine kinase]] | [[Category: Histidine kinase]] | ||
Revision as of 15:24, 25 December 2014
Structure of the Sda antikinase
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