2e2s
From Proteopedia
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| - | [[Image:2e2s.jpg|left|200px]] | + | [[Image:2e2s.jpg|left|200px]] |
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| - | '''Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta''' | + | {{Structure |
| + | |PDB= 2e2s |SIZE=350|CAPTION= <scene name='initialview01'>2e2s</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2E2S is a [ | + | 2E2S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agelena_opulenta Agelena opulenta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E2S OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors., Yamaji N, Sugase K, Nakajima T, Miki T, Wakamori M, Mori Y, Iwashita T, FEBS Lett. 2007 Aug 7;581(20):3789-94. Epub 2007 Jul 10. PMID:[http:// | + | Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors., Yamaji N, Sugase K, Nakajima T, Miki T, Wakamori M, Mori Y, Iwashita T, FEBS Lett. 2007 Aug 7;581(20):3789-94. Epub 2007 Jul 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17644092 17644092] |
[[Category: Agelena opulenta]] | [[Category: Agelena opulenta]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: toxin]] | [[Category: toxin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:34:34 2008'' |
Revision as of 14:34, 20 March 2008
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Solution structure of agelenin, an insecticidal peptide from the venom of Agelena opulenta
Overview
Agelenin, isolated from the Agelenidae spider Agelena opulenta, is a peptide composed of 35 amino acids. We determined the three-dimensional structure of agelenin using two-dimensional NMR spectroscopy. The structure is composed of a short antiparallel beta-sheet and four beta-turns, which are stabilized by three disulfide bonds. Agelenin has characteristic residues, Phe9, Ser28 and Arg33, which are arranged similarly to the pharmacophore of the insect channel inhibitor, omega-atracotoxin-Hv1a. These observations suggest that agelenin and omega-atracotoxin-Hv1a bind to insect calcium channels in a similar manner. We also suggest that another mode of action may operate in the channel inhibition by omega-agatoxin-IVA and omega-atracotoxin-Hv2a.
About this Structure
2E2S is a Single protein structure of sequence from Agelena opulenta. Full crystallographic information is available from OCA.
Reference
Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors., Yamaji N, Sugase K, Nakajima T, Miki T, Wakamori M, Mori Y, Iwashita T, FEBS Lett. 2007 Aug 7;581(20):3789-94. Epub 2007 Jul 10. PMID:17644092
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