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3tnz
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3tnz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TNZ FirstGlance]. <br> | <table><tr><td colspan='2'>[[3tnz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TNZ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IYR:3-IODO-TYROSINE'>IYR</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IYR:3-IODO-TYROSINE'>IYR</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gb5|3gb5]], [[3gfd|3gfd]], [[3gh8|3gh8]], [[3to0|3to0]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gb5|3gb5]], [[3gfd|3gfd]], [[3gh8|3gh8]], [[3to0|3to0]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dehal1, Iyd, IYD-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dehal1, Iyd, IYD-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iodotyrosine_deiodinase Iodotyrosine deiodinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.22.1.1 1.22.1.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iodotyrosine_deiodinase Iodotyrosine deiodinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.22.1.1 1.22.1.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tnz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tnz RCSB], [http://www.ebi.ac.uk/pdbsum/3tnz PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tnz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tnz RCSB], [http://www.ebi.ac.uk/pdbsum/3tnz PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IYD1_MOUSE IYD1_MOUSE]] Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Expression of a soluble form of iodotyrosine deiodinase for active site characterization by engineering the native membrane protein from mus musculus.,Buss JM, McTamney PM, Rokita TE Protein Sci. 2012 Jan 11. doi: 10.1002/pro.2020. PMID:22238141<ref>PMID:22238141</ref> | Expression of a soluble form of iodotyrosine deiodinase for active site characterization by engineering the native membrane protein from mus musculus.,Buss JM, McTamney PM, Rokita TE Protein Sci. 2012 Jan 11. doi: 10.1002/pro.2020. PMID:22238141<ref>PMID:22238141</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dehalogenase|Dehalogenase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 23: | Line 28: | ||
[[Category: Iodotyrosine deiodinase]] | [[Category: Iodotyrosine deiodinase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Buss, J M | + | [[Category: Buss, J M]] |
| - | [[Category: McTamney, P M | + | [[Category: McTamney, P M]] |
| - | [[Category: Rokita, S E | + | [[Category: Rokita, S E]] |
[[Category: Dehalogenase]] | [[Category: Dehalogenase]] | ||
[[Category: Flavoprotein]] | [[Category: Flavoprotein]] | ||
Revision as of 15:31, 25 December 2014
Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) C217A, C239A bound to FMN and mono-iodotyrosine (MIT)
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