3q3j
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q3j RCSB], [http://www.ebi.ac.uk/pdbsum/3q3j PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q3j RCSB], [http://www.ebi.ac.uk/pdbsum/3q3j PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PLXA2_HUMAN PLXA2_HUMAN]] Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). [[http://www.uniprot.org/uniprot/RND1_HUMAN RND1_HUMAN]] Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.<ref>PMID:11095956</ref> | ||
==See Also== | ==See Also== | ||
*[[GTP-binding protein|GTP-binding protein]] | *[[GTP-binding protein|GTP-binding protein]] | ||
*[[Plexin|Plexin]] | *[[Plexin|Plexin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 15:46, 25 December 2014
Crystal structure of plexin A2 RBD in complex with Rnd1
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Categories: Homo sapiens | Arrowsmith, C H | Bountra, C | Buren, L | Crombet, L | Edwards, A M | Guan, X | Park, H | Structural genomic | Shen, L | Tempel, W | Tong, Y | Wang, H | Weigelt, J | Wernimont, A K | Zhang, N | Membrane protein-protein binding complex | Plexin | Ras-binding domain | Sgc | Small gtpase
