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1irh
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1irh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IRH FirstGlance]. <br> | <table><tr><td colspan='2'>[[1irh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IRH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IRH FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1irh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1irh RCSB], [http://www.ebi.ac.uk/pdbsum/1irh PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1irh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1irh RCSB], [http://www.ebi.ac.uk/pdbsum/1irh PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TFPI1_HUMAN TFPI1_HUMAN]] Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hara, S | + | [[Category: Hara, S]] |
| - | [[Category: Kato, H | + | [[Category: Kato, H]] |
| - | [[Category: Mine, S | + | [[Category: Mine, S]] |
| - | [[Category: Miyata, T | + | [[Category: Miyata, T]] |
| - | [[Category: Yamazaki, T | + | [[Category: Yamazaki, T]] |
[[Category: Kunitz domain]] | [[Category: Kunitz domain]] | ||
[[Category: Non-protease inhibitor]] | [[Category: Non-protease inhibitor]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 16:17, 25 December 2014
The Solution Structure of The Third Kunitz Domain of Tissue Factor Pathway Inhibitor
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