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1yj5
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yj5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YJ5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1yj5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YJ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YJ5 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_5'-hydroxyl-kinase Polynucleotide 5'-hydroxyl-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.78 2.7.1.78] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_5'-hydroxyl-kinase Polynucleotide 5'-hydroxyl-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.78 2.7.1.78] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yj5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yj5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yj5 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yj5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yj5 RCSB], [http://www.ebi.ac.uk/pdbsum/1yj5 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PNKP_MOUSE PNKP_MOUSE]] Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 32: | Line 34: | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Polynucleotide 5'-hydroxyl-kinase]] | [[Category: Polynucleotide 5'-hydroxyl-kinase]] | ||
| - | [[Category: Bernstein, N K | + | [[Category: Bernstein, N K]] |
| - | [[Category: Cass, C E | + | [[Category: Cass, C E]] |
| - | [[Category: Cui, D | + | [[Category: Cui, D]] |
| - | [[Category: Durocher, D | + | [[Category: Durocher, D]] |
| - | [[Category: Galicia, S | + | [[Category: Galicia, S]] |
| - | [[Category: Glover, J N.M | + | [[Category: Glover, J N.M]] |
| - | [[Category: Green, R | + | [[Category: Green, R]] |
| - | [[Category: Karimi-Busheri, F | + | [[Category: Karimi-Busheri, F]] |
| - | [[Category: Koch, C A | + | [[Category: Koch, C A]] |
| - | [[Category: Mani, R S | + | [[Category: Mani, R S]] |
| - | [[Category: Rakovszky, M L | + | [[Category: Rakovszky, M L]] |
| - | [[Category: Weinfeld, M | + | [[Category: Weinfeld, M]] |
| - | [[Category: Williams, R S | + | [[Category: Williams, R S]] |
[[Category: Beta sandwich]] | [[Category: Beta sandwich]] | ||
[[Category: P-loop]] | [[Category: P-loop]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 16:21, 25 December 2014
Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme
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