2xgk

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xgk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Minute_virus_of_mice Minute virus of mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XGK FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xgk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Minute_virus_of_mice Minute virus of mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XGK FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mvm|1mvm]], [[1z1c|1z1c]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mvm|1mvm]], [[1z1c|1z1c]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xgk RCSB], [http://www.ebi.ac.uk/pdbsum/2xgk PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xgk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xgk RCSB], [http://www.ebi.ac.uk/pdbsum/2xgk PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/COAT_MUMIM COAT_MUMIM]] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of two size variants of the capsid proteins, VP1 and VP2, which differ by the presence of an N-terminal extension in the minor protein VP1. The capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptors also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Minute virus of mice]]
[[Category: Minute virus of mice]]
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[[Category: Abramo, A D.]]
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[[Category: Abramo, A D]]
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[[Category: Cotmore, S.]]
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[[Category: Cotmore, S]]
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[[Category: Farr, G.]]
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[[Category: Farr, G]]
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[[Category: Hafenstein, S.]]
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[[Category: Hafenstein, S]]
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[[Category: Plevka, P.]]
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[[Category: Plevka, P]]
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[[Category: Rossmann, M G.]]
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[[Category: Rossmann, M G]]
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[[Category: Tattersall, P.]]
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[[Category: Tattersall, P]]
[[Category: Parvovirus]]
[[Category: Parvovirus]]
[[Category: Virus]]
[[Category: Virus]]
[[Category: Vlp]]
[[Category: Vlp]]

Revision as of 16:24, 25 December 2014

VIRUS LIKE PARTICLE OF L172W MUTANT OF MINUTE VIRUS OF MICE - THE IMMUNOSUPPRESSIVE STRAIN

2xgk, resolution 4.20Å

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