3d65

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3d65]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Pseudonaja_textilis_textilis Pseudonaja textilis textilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D65 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3d65]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Pseudonaja_textilis_textilis Pseudonaja textilis textilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D65 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D65 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3byb|3byb]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3byb|3byb]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d65 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d65 RCSB], [http://www.ebi.ac.uk/pdbsum/3d65 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d65 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d65 RCSB], [http://www.ebi.ac.uk/pdbsum/3d65 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/IVBI1_PSETT IVBI1_PSETT]] Strongly inhibits plasmin and trypsin. Has little effect on plasma and tissue kallikrein. Has no effect on tissue plasminogen inhibitor (t-PA), urokinase, activated protein C (APC) and elastase. Strongly inhibits whole blood clot lysis.<ref>PMID:12406072</ref> <ref>PMID:10847427</ref> <ref>PMID:16707925</ref> <ref>PMID:19236611</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Trypsin|Trypsin]]
*[[Trypsin|Trypsin]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pseudonaja textilis textilis]]
[[Category: Pseudonaja textilis textilis]]
[[Category: Trypsin]]
[[Category: Trypsin]]
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[[Category: Guddat, L W.]]
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[[Category: Guddat, L W]]
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[[Category: Jersey, J de.]]
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[[Category: Jersey, J de]]
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[[Category: Lavin, M F.]]
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[[Category: Lavin, M F]]
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[[Category: Masci, P P.]]
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[[Category: Masci, P P]]
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[[Category: Millers, E K.I.]]
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[[Category: Millers, E K.I]]
[[Category: Blood]]
[[Category: Blood]]
[[Category: Coagulation]]
[[Category: Coagulation]]
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
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[[Category: Trypsin]]
 
[[Category: Zymogen]]
[[Category: Zymogen]]

Revision as of 16:29, 25 December 2014

Crystal structure of Textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom, in complex with trypsin

3d65, resolution 1.64Å

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