4qdl
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4qdl]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QDL FirstGlance]. <br> | <table><tr><td colspan='2'>[[4qdl]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QDL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qdl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qdl RCSB], [http://www.ebi.ac.uk/pdbsum/4qdl PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qdl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qdl RCSB], [http://www.ebi.ac.uk/pdbsum/4qdl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAS1_ECOLI CAS1_ECOLI]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas1 is thought to be involved in CRISPR adaptation, the first stage of CRISPR immunity. Might be involved in the addition/removal of CRISPR spacers. Endonucleolytically cleaves linear ssRNA, ssDNA and short (34 base) dsDNA as well as branched DNA substrates such as Holliday junctions, replication forks and 5'-flap DNA substrates. Genetic interactions suggest Cas1 interacts with components of the RecBC and RuvB DNA repair systems.<ref>PMID:21255106</ref> [[http://www.uniprot.org/uniprot/CAS2_ECOLI CAS2_ECOLI]] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity).<ref>PMID:21255106</ref> | ||
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| + | ==See Also== | ||
| + | *[[Endonuclease|Endonuclease]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Gasiunas, G | + | [[Category: Gasiunas, G]] |
| - | [[Category: Grazulis, S | + | [[Category: Grazulis, S]] |
| - | [[Category: Siksnys, V | + | [[Category: Siksnys, V]] |
| - | [[Category: Silanskas, A | + | [[Category: Silanskas, A]] |
| - | [[Category: Sinkunas, T | + | [[Category: Sinkunas, T]] |
| - | [[Category: Tamulaitiene, G | + | [[Category: Tamulaitiene, G]] |
[[Category: Cas1-cas2 complex]] | [[Category: Cas1-cas2 complex]] | ||
[[Category: Crispr adaptation]] | [[Category: Crispr adaptation]] | ||
[[Category: Crispr-ca]] | [[Category: Crispr-ca]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 16:30, 25 December 2014
Crystal structure of E.coli Cas1-Cas2 complex
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