1yui
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yui RCSB], [http://www.ebi.ac.uk/pdbsum/1yui PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yui OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yui RCSB], [http://www.ebi.ac.uk/pdbsum/1yui PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GAGA_DROME GAGA_DROME]] Transcriptional activator that functions by regulating chromatin structure. Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors. Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones. Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3'. Binds DNA as an oligomer. May also act as a transcriptional repressor, maintaining the repressed state of genes including lolal, and down-regulating its own transcription. Required for dosage compensation in males and may be involved in oogenesis. Also has a role in nuclear division.<ref>PMID:7504178</ref> <ref>PMID:9241251</ref> <ref>PMID:8620838</ref> <ref>PMID:12200449</ref> <ref>PMID:12815073</ref> <ref>PMID:12834867</ref> <ref>PMID:15063171</ref> <ref>PMID:15020425</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
| - | [[Category: Clore, G M | + | [[Category: Clore, G M]] |
| - | [[Category: Gronenborn, A M | + | [[Category: Gronenborn, A M]] |
| - | [[Category: Omichinski, J G | + | [[Category: Omichinski, J G]] |
[[Category: Chromatin remodeling]] | [[Category: Chromatin remodeling]] | ||
[[Category: Dna binding protein-dna complex]] | [[Category: Dna binding protein-dna complex]] | ||
Revision as of 16:30, 25 December 2014
SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, REGULARIZED MEAN STRUCTURE
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