1y2t
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1y2t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agaricus_bisporus Agaricus bisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2T FirstGlance]. <br> | <table><tr><td colspan='2'>[[1y2t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agaricus_bisporus Agaricus bisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y2T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Y2T FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y2u|1y2u]], [[1y2v|1y2v]], [[1y2w|1y2w]], [[1y2x|1y2x]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y2u|1y2u]], [[1y2v|1y2v]], [[1y2w|1y2w]], [[1y2x|1y2x]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2t RCSB], [http://www.ebi.ac.uk/pdbsum/1y2t PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y2t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1y2t RCSB], [http://www.ebi.ac.uk/pdbsum/1y2t PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ABL_AGABI ABL_AGABI]] Lectin that recognizes O-linked galactose-beta-1,3-N-acetylgalactosamine, a disaccharide (Thomsen-Friedenreich antigen or T-disaccharide), present on cell surface glycoproteins. Can also bind galactose-beta-1,3-N-acetylglucosamine. Does not bind monosaccharides. Can be internalized by clathrin-coated vesicles after binding to surface glycoproteins. After internalization it inhibits nuclear import of nuclear localization signal dependent proteins. Inhibits proliferation of malignant cells without cytotoxicity for normal cells.<ref>PMID:4343164</ref> <ref>PMID:8402638</ref> <ref>PMID:9988731</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Agaricus bisporus]] | [[Category: Agaricus bisporus]] | ||
| - | [[Category: Capaldi, S | + | [[Category: Capaldi, S]] |
| - | [[Category: Carrizo, M E | + | [[Category: Carrizo, M E]] |
| - | [[Category: Irazoqui, F J | + | [[Category: Irazoqui, F J]] |
| - | [[Category: Monaco, H L | + | [[Category: Monaco, H L]] |
| - | [[Category: Nores, G A | + | [[Category: Nores, G A]] |
| - | [[Category: Perduca, M | + | [[Category: Perduca, M]] |
[[Category: Abl]] | [[Category: Abl]] | ||
| - | [[Category: Agaricus bisporus]] | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Mushroom]] | [[Category: Mushroom]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 16:33, 25 December 2014
Crystal structure of the common edible mushroom (Agaricus bisporus) lectin
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