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2v9u
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v9u]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9U FirstGlance]. <br> | <table><tr><td colspan='2'>[[2v9u]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9U FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uun|1uun]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1uun|1uun]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v9u RCSB], [http://www.ebi.ac.uk/pdbsum/2v9u PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v9u RCSB], [http://www.ebi.ac.uk/pdbsum/2v9u PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9RLP7_MYCSM Q9RLP7_MYCSM]] The major porin in this organism, forms a water-filled channel which favors the permeation of cations, amino acids, iron Fe(3+) and less efficiently phosphate. Does not transport Fe-ExoMS, the predominant siderophore. Plays a role in transport of beta-lactamase and hydrophilic fluoroquinolone antibiotics such as norfloxacin as well as chloramphenicol. There are about 2400 porins in wild-type, 800 in an mspA deletion and 150 in a double mspA-mspC deletion. Different conductance values with maxima at 2.3 and 4.6 nanosiemens might be caused by a simultaneous reconstitution of MspA channels into the membrane or by the existence of different MspA conformations.<ref>PMID:10476028</ref> <ref>PMID:16238622</ref> <ref>PMID:17209034</ref> <ref>PMID:18559650</ref> <ref>PMID:20952578</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mycobacterium smegmatis]] | [[Category: Mycobacterium smegmatis]] | ||
| - | [[Category: Grueninger, D | + | [[Category: Grueninger, D]] |
| - | [[Category: Koetter, J W.A | + | [[Category: Koetter, J W.A]] |
| - | [[Category: Schulz, G E | + | [[Category: Schulz, G E]] |
| - | [[Category: Schulze, M S | + | [[Category: Schulze, M S]] |
| - | [[Category: Treiber, N | + | [[Category: Treiber, N]] |
| - | [[Category: Ziegler, M O.P | + | [[Category: Ziegler, M O.P]] |
[[Category: Mycobacteria]] | [[Category: Mycobacteria]] | ||
[[Category: Pori]] | [[Category: Pori]] | ||
[[Category: Porin]] | [[Category: Porin]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 16:36, 25 December 2014
RIM DOMAIN OF MAIN PORIN FROM MYCOBACTERIA SMEGMATIS
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