This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

2gse

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 16:46, 25 December 2014

Crystal Structure of Human Dihydropyrimidinease-like 2

Structural highlights

2gse is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	DPYSL2 (Homo sapiens)
Activity:	Dihydropyrimidinase, with EC number 3.5.2.2
Resources:	FirstGlance, OCA, RCSB, PDBsum

Function

[DPYL2_HUMAN] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Axonal growth cone guidance is a central process in nervous system development and repair. Collapsin response mediator protein 2 (CRMP-2) is a neurite extension-promoting neuronal cytosolic molecule involved in the signalling of growth inhibitory cues from external stimuli, such as semaphorin 3A and the myelin-associated glycoprotein. We have determined the crystal structure of human tetrameric CRMP-2, which is structurally related to the dihydropyriminidases; however, the active site is not conserved. The wealth of earlier functional mapping data for CRMP-2 are discussed in light of the three-dimensional structure of the protein. The differences in oligomerisation interfaces between CRMP-1 and CRMP-2 are used to model CRMP-1/2 heterotetramers.

The structure of human collapsin response mediator protein 2, a regulator of axonal growth.,Stenmark P, Ogg D, Flodin S, Flores A, Kotenyova T, Nyman T, Nordlund P, Kursula P J Neurochem. 2007 May;101(4):906-17. Epub 2007 Jan 22. PMID:17250651^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Inagaki N, Chihara K, Arimura N, Menager C, Kawano Y, Matsuo N, Nishimura T, Amano M, Kaibuchi K. CRMP-2 induces axons in cultured hippocampal neurons. Nat Neurosci. 2001 Aug;4(8):781-2. PMID:11477421 doi:http://dx.doi.org/10.1038/90476
↑ Cole AR, Knebel A, Morrice NA, Robertson LA, Irving AJ, Connolly CN, Sutherland C. GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J Biol Chem. 2004 Nov 26;279(48):50176-80. Epub 2004 Oct 5. PMID:15466863 doi:http://dx.doi.org/10.1074/jbc.C400412200
↑ Stenmark P, Ogg D, Flodin S, Flores A, Kotenyova T, Nyman T, Nordlund P, Kursula P. The structure of human collapsin response mediator protein 2, a regulator of axonal growth. J Neurochem. 2007 May;101(4):906-17. Epub 2007 Jan 22. PMID:17250651 doi:10.1111/j.1471-4159.2006.04401.x

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gse"

@@ Line 3: / Line 3: @@
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2gse]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GSE FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DPYSL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DPYSL2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropyrimidinase Dihydropyrimidinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.2 3.5.2.2] </span></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydropyrimidinase Dihydropyrimidinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.2 3.5.2.2] </span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gse OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gse RCSB], [http://www.ebi.ac.uk/pdbsum/2gse PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gse OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gse RCSB], [http://www.ebi.ac.uk/pdbsum/2gse PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DPYL2_HUMAN DPYL2_HUMAN]] Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis.<ref>PMID:11477421</ref> <ref>PMID:15466863</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 32: / Line 34: @@
 [[Category: Dihydropyrimidinase]]
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.]]
+[[Category: Arrowsmith, C]]
-[[Category: Berg, S Van Den.]]
+[[Category: Berg, S Van Den]]
-[[Category: Berglund, H.]]
+[[Category: Berglund, H]]
-[[Category: Collins, R.]]
+[[Category: Collins, R]]
-[[Category: Edwards, A.]]
+[[Category: Edwards, A]]
-[[Category: Ehn, M.]]
+[[Category: Ehn, M]]
-[[Category: Flodin, S.]]
+[[Category: Flodin, S]]
-[[Category: Flores, A.]]
+[[Category: Flores, A]]
-[[Category: Graslund, S.]]
+[[Category: Graslund, S]]
-[[Category: Hallberg, B M.]]
+[[Category: Hallberg, B M]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hammarstrom, M]]
-[[Category: Holmberg-Schiavone, L.]]
+[[Category: Holmberg-Schiavone, L]]
-[[Category: Kotenyova, T.]]
+[[Category: Kotenyova, T]]
-[[Category: Kursula, P.]]
+[[Category: Kursula, P]]
-[[Category: Nilsson-Ehle, P.]]
+[[Category: Nilsson-Ehle, P]]
-[[Category: Nordlund, P.]]
+[[Category: Nordlund, P]]
-[[Category: Nyman, T.]]
+[[Category: Nyman, T]]
-[[Category: Ogg, D.]]
+[[Category: Ogg, D]]
-[[Category: Persson, C.]]
+[[Category: Persson, C]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Structural genomic]]
-[[Category: Sagemark, J.]]
+[[Category: Sagemark, J]]
-[[Category: Stenmark, P.]]
+[[Category: Stenmark, P]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom, M]]
 [[Category: Thorsell, A G]]
-[[Category: Uppenberg, J.]]
+[[Category: Uppenberg, J]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt, J]]
 [[Category: Alpha/beta barrel]]
 [[Category: Collapsin response mediator protein 2]]
@@ Line 65: / Line 67: @@
 [[Category: Hydrolase]]
 [[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]

2gse

From Proteopedia

Revision as of 16:46, 25 December 2014

Crystal Structure of Human Dihydropyrimidinease-like 2

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox