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3d8v
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(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d8v RCSB], [http://www.ebi.ac.uk/pdbsum/3d8v PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d8v RCSB], [http://www.ebi.ac.uk/pdbsum/3d8v PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLMU_MYCTU GLMU_MYCTU]] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.<ref>PMID:19237750</ref> <ref>PMID:19121323</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 16:50, 25 December 2014
Crystal structure of GlmU from Mycobacterium tuberculosis in complex with uridine-diphosphate-N-acetylglucosamine
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Categories: Mycobacterium tuberculosis | Baker, E N | Squire, C J | Zhang, Z | Acyltransferase | Cell shape | Cell wall biogenesis/degradation | Magnesium | Metal-binding | Multifunctional enzyme | Nucleotide-diphospho-sugar transferases/single-stranded left-handed beta-helix | Nucleotidyltransferase | Peptidoglycan synthesis | Transferase
