2qfj
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qfj RCSB], [http://www.ebi.ac.uk/pdbsum/2qfj PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qfj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qfj RCSB], [http://www.ebi.ac.uk/pdbsum/2qfj PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PUF60_HUMAN PUF60_HUMAN]] DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with TROVE2. Binds to poly(U) RNA.<ref>PMID:10882074</ref> <ref>PMID:10606266</ref> <ref>PMID:11239393</ref> <ref>PMID:16452196</ref> <ref>PMID:16628215</ref> <ref>PMID:17579712</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Braddock, D | + | [[Category: Braddock, D]] |
| - | [[Category: Crichlow, G V | + | [[Category: Crichlow, G V]] |
| - | [[Category: Fan, C | + | [[Category: Fan, C]] |
| - | [[Category: Lolis, E | + | [[Category: Lolis, E]] |
| - | [[Category: Yang, Y | + | [[Category: Yang, Y]] |
[[Category: Protein-dna complex]] | [[Category: Protein-dna complex]] | ||
[[Category: Rrm domain]] | [[Category: Rrm domain]] | ||
[[Category: Transcription repressor-dna complex]] | [[Category: Transcription repressor-dna complex]] | ||
Revision as of 16:52, 25 December 2014
Crystal Structure of First Two RRM Domains of FIR Bound to ssDNA from a Portion of FUSE
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