2kbk
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBK FirstGlance]. <br> | <table><tr><td colspan='2'>[[2kbk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KBK FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kbh|2kbh]], [[2kbj|2kbj]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kbh|2kbh]], [[2kbj|2kbj]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kbk RCSB], [http://www.ebi.ac.uk/pdbsum/2kbk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kbk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kbk RCSB], [http://www.ebi.ac.uk/pdbsum/2kbk PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SCXA_MESMA SCXA_MESMA]] Binds to voltage-dependent sodium channels (Nav) and voltage-dependent delayed rectifier potassium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Administration to mice at a dosage of 0.8 mg/kg produces an analgesic effect. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
| - | [[Category: Wu, H | + | [[Category: Wu, H]] |
| - | [[Category: Zhu, J | + | [[Category: Zhu, J]] |
[[Category: Ionic channel inhibitor]] | [[Category: Ionic channel inhibitor]] | ||
[[Category: Neurotoxin]] | [[Category: Neurotoxin]] | ||
Revision as of 17:06, 25 December 2014
Solution Structure of BmK-M10
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