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3ckw
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ckw RCSB], [http://www.ebi.ac.uk/pdbsum/3ckw PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3ckw TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ckw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ckw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ckw RCSB], [http://www.ebi.ac.uk/pdbsum/3ckw PDBsum], [http://www.topsan.org/Proteins/NYSGXRC/3ckw TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/STK24_HUMAN STK24_HUMAN]] Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.<ref>PMID:16314523</ref> <ref>PMID:17046825</ref> <ref>PMID:19604147</ref> <ref>PMID:19855390</ref> <ref>PMID:19782762</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | *[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 17:10, 25 December 2014
Crystal structure of sterile 20-like kinase 3 (MST3, STK24)
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Categories: Homo sapiens | Non-specific serine/threonine protein kinase | Antonysamy, S S | Buchanan, S | Burley, S K | Chau, F | Feil, I | Structural genomic | Sauder, J M | Wu, L | Atp-binding | Mst3 | Nucleotide-binding | NYSGXRC, New York SGX Research Center for Structural Genomics | Phosphoprotein | Protein kinase | PSI, Protein structure initiative | Serine/threonine-protein kinase | Sterile 20-like kinase | Stk24 | Transferase
