2yly
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
<StructureSection load='2yly' size='340' side='right' caption='[[2yly]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='2yly' size='340' side='right' caption='[[2yly]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA]. <br> | + | <table><tr><td colspan='2'>[[2yly]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YLY FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SU4:N-CYCLOPROPYL-4-OXIDANYL-N-[(2R)-2-OXIDANYL-2-PHENYL-PROPYL]BENZENESULFONAMIDE'>SU4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yy4|1yy4]], [[1u3s|1u3s]], [[1x78|1x78]], [[1qkm|1qkm]], [[1u3r|1u3r]], [[1l2j|1l2j]], [[2fsz|2fsz]], [[1x7j|1x7j]], [[1x7b|1x7b]], [[1u9e|1u9e]], [[1x76|1x76]], [[1nde|1nde]], [[1yye|1yye]], [[2jj3|2jj3]], [[1u3q|1u3q]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1yy4|1yy4]], [[1u3s|1u3s]], [[1x78|1x78]], [[1qkm|1qkm]], [[1u3r|1u3r]], [[1l2j|1l2j]], [[2fsz|2fsz]], [[1x7j|1x7j]], [[1x7b|1x7b]], [[1u9e|1u9e]], [[1x76|1x76]], [[1nde|1nde]], [[1yye|1yye]], [[2jj3|2jj3]], [[1u3q|1u3q]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yly OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yly RCSB], [http://www.ebi.ac.uk/pdbsum/2yly PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 15: | ||
Sulfonamides as selective oestrogen receptor beta agonists.,Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. Epub 2011 Aug 16. PMID:21885279<ref>PMID:21885279</ref> | Sulfonamides as selective oestrogen receptor beta agonists.,Roberts LR, Armor D, Barker C, Bent A, Bess K, Brown A, Favor DA, Ellis D, Irving SL, MacKenny M, Phillips C, Pullen N, Stennett A, Strand L, Styles M Bioorg Med Chem Lett. 2011 Oct 1;21(19):5680-3. Epub 2011 Aug 16. PMID:21885279<ref>PMID:21885279</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Estrogen receptor|Estrogen receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 21: | Line 25: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Armour, D | + | [[Category: Armour, D]] |
| - | [[Category: Barker, C | + | [[Category: Barker, C]] |
| - | [[Category: Bazin, R | + | [[Category: Bazin, R]] |
| - | [[Category: Bess, K | + | [[Category: Bess, K]] |
| - | [[Category: Brown, A | + | [[Category: Brown, A]] |
| - | [[Category: Ellis, D | + | [[Category: Ellis, D]] |
| - | [[Category: Favor, D | + | [[Category: Favor, D]] |
| - | [[Category: Mackenny, M | + | [[Category: Mackenny, M]] |
| - | [[Category: Phillips, C | + | [[Category: Phillips, C]] |
| - | [[Category: Pullen, N | + | [[Category: Pullen, N]] |
| - | [[Category: Roberts, L R | + | [[Category: Roberts, L R]] |
| - | [[Category: Stennett, A | + | [[Category: Stennett, A]] |
| - | [[Category: Strand, L | + | [[Category: Strand, L]] |
| - | [[Category: Styles, M | + | [[Category: Styles, M]] |
[[Category: Receptor]] | [[Category: Receptor]] | ||
Revision as of 17:22, 25 December 2014
Sulfonamides as selective Estrogen Receptor beta Agonists.
| |||||||||||
Categories: Homo sapiens | Armour, D | Barker, C | Bazin, R | Bess, K | Brown, A | Ellis, D | Favor, D | Mackenny, M | Phillips, C | Pullen, N | Roberts, L R | Stennett, A | Strand, L | Styles, M | Receptor
