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3ne0
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ne0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ne0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ne0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ne0 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ne0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ne0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ne0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ne0 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/O53168_MYCTU O53168_MYCTU]] Peptidoglycan endopeptidase that cleaves the bond between D-glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of Actinobacteria; activity is increased in the presence of RpfB and inhibited by PBP1A (ponA1). Required for normal separation of daughter cells after cell division and for cell wall integrity. Required for host cell invasion and intracellular survival in host macrophages.<ref>PMID:16495549</ref> <ref>PMID:17919286</ref> <ref>PMID:18463693</ref> <ref>PMID:20826344</ref> <ref>PMID:21864539</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 18:00, 25 December 2014
Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation
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