3icu
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3icu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3icu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3icu RCSB], [http://www.ebi.ac.uk/pdbsum/3icu PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3icu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3icu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3icu RCSB], [http://www.ebi.ac.uk/pdbsum/3icu PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RN128_HUMAN RN128_HUMAN]] E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity).<ref>PMID:12705856</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 20: | Line 22: | ||
==See Also== | ==See Also== | ||
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | *[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:01, 25 December 2014
Protease-associated domain of the E3 ligase grail
| |||||||||||
Categories: Homo sapiens | Arrowsmith, C H | Bochkarev, A | Bountra, C | Dhe-Paganon, S | Edwards, A M | Structural genomic | Seitova, A | Walker, J R | Weigelt, J | Yermekbayeva, L | E3 ligase | Energy | Glycoprotein | Ligase | Membrane | Metal-binding | Pa domain | Protein turnover | Sgc | Transmembrane | Ubl conjugation pathway | Zinc-finger
