2r9o

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2r9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9O FirstGlance]. <br>
<table><tr><td colspan='2'>[[2r9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2R9O FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y15:N-[(1S)-2-{[(1R)-2-(BENZYLOXY)-1-CYANO-1-METHYLETHYL]AMINO}-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y15</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y15:N-[(1S)-2-{[(1R)-2-(BENZYLOXY)-1-CYANO-1-METHYLETHYL]AMINO}-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y15</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r9m|2r9m]], [[2r9n|2r9n]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2r9m|2r9m]], [[2r9n|2r9n]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9o RCSB], [http://www.ebi.ac.uk/pdbsum/2r9o PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2r9o RCSB], [http://www.ebi.ac.uk/pdbsum/2r9o PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Cathepsin S]]
[[Category: Cathepsin S]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bekkali, Y.]]
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[[Category: Bekkali, Y]]
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[[Category: Brown, M L.]]
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[[Category: Brown, M L]]
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[[Category: Capolino, A.]]
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[[Category: Capolino, A]]
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[[Category: Crane, K M.]]
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[[Category: Crane, K M]]
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[[Category: DeTuri, M.]]
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[[Category: DeTuri, M]]
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[[Category: Emmanuel, M J.]]
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[[Category: Emmanuel, M J]]
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[[Category: Freeman, D.]]
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[[Category: Freeman, D]]
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[[Category: Frye, L L.]]
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[[Category: Frye, L L]]
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[[Category: Girardot, M.]]
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[[Category: Girardot, M]]
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[[Category: Grygon, C A.]]
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[[Category: Grygon, C A]]
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[[Category: Hao, M H.]]
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[[Category: Hao, M H]]
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[[Category: Hrapchak, M.]]
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[[Category: Hrapchak, M]]
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[[Category: Labadia, M E.]]
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[[Category: Labadia, M E]]
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[[Category: Liu, W.]]
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[[Category: Liu, W]]
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[[Category: Morwick, T.]]
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[[Category: Morwick, T]]
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[[Category: Nelson, R.]]
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[[Category: Nelson, R]]
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[[Category: Peterson, J D.]]
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[[Category: Peterson, J D]]
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[[Category: Raymond, E L.]]
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[[Category: Raymond, E L]]
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[[Category: Spero, D M.]]
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[[Category: Spero, D M]]
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[[Category: Thomson, D S.]]
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[[Category: Thomson, D S]]
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[[Category: Wang, Y.]]
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[[Category: Wang, Y]]
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[[Category: Ward, Y D.]]
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[[Category: Ward, Y D]]
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[[Category: White, A.]]
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[[Category: White, A]]
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[[Category: White, D M.]]
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[[Category: White, D M]]
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[[Category: Wildeson, J.]]
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[[Category: Wildeson, J]]
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[[Category: Young, E R.R.]]
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[[Category: Young, E R.R]]
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[[Category: Zindell, R.]]
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[[Category: Zindell, R]]
[[Category: Cathepsin]]
[[Category: Cathepsin]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]

Revision as of 18:06, 25 December 2014

Cathepsin S complexed with Compound 8

2r9o, resolution 2.00Å

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OCA

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