1s2h

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1s2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S2H FirstGlance]. <br>
<table><tr><td colspan='2'>[[1s2h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1S2H FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1duj|1duj]], [[1klq|1klq]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1duj|1duj]], [[1klq|1klq]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAD2L1, MAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAD2L1, MAD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s2h RCSB], [http://www.ebi.ac.uk/pdbsum/1s2h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1s2h RCSB], [http://www.ebi.ac.uk/pdbsum/1s2h PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MD2L1_HUMAN MD2L1_HUMAN]] Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.<ref>PMID:10700282</ref> <ref>PMID:11804586</ref> <ref>PMID:15024386</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Luo, X.]]
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[[Category: Luo, X]]
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[[Category: Matsumoto, T.]]
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[[Category: Matsumoto, T]]
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[[Category: Rizo, J.]]
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[[Category: Rizo, J]]
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[[Category: Tang, Z.]]
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[[Category: Tang, Z]]
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[[Category: Wassmann, K.]]
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[[Category: Wassmann, K]]
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[[Category: Xia, G.]]
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[[Category: Xia, G]]
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[[Category: Yu, H.]]
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[[Category: Yu, H]]
[[Category: Cell cycle]]
[[Category: Cell cycle]]
[[Category: Mad2]]
[[Category: Mad2]]
[[Category: Spindle checkpoint protein]]
[[Category: Spindle checkpoint protein]]

Revision as of 18:13, 25 December 2014

The Mad2 spindle checkpoint protein possesses two distinct natively folded states

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