3f5o
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5o RCSB], [http://www.ebi.ac.uk/pdbsum/3f5o PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3f5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f5o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3f5o RCSB], [http://www.ebi.ac.uk/pdbsum/3f5o PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/THEM2_HUMAN THEM2_HUMAN]] Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).<ref>PMID:16934754</ref> <ref>PMID:19170545</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 18:16, 25 December 2014
Crystal Structure of hTHEM2(undecan-2-one-CoA) complex
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Categories: Homo sapiens | Gong, W | Xu, H | Hotdog fold | Hydrolase
