2wpo
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wpo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_5 Human herpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WPO FirstGlance]. <br> | <table><tr><td colspan='2'>[[2wpo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_5 Human herpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WPO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WPO FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=01E:(2S)-2-(3,3-DIMETHYLBUTANOYLAMINO)-N-[(2S)-1-[[(2S,3S)-3-HYDROXY-4-[(4-IODOPHENYL)METHYLAMINO]-4-OXO-BUTAN-2-YL]AMINO]-1,4-DIOXO-4-PYRROL-1-YL-BUTAN-2-YL]-3,3-DIMETHYL-BUTANAMIDE'>01E</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=01E:(2S)-2-(3,3-DIMETHYLBUTANOYLAMINO)-N-[(2S)-1-[[(2S,3S)-3-HYDROXY-4-[(4-IODOPHENYL)METHYLAMINO]-4-OXO-BUTAN-2-YL]AMINO]-1,4-DIOXO-4-PYRROL-1-YL-BUTAN-2-YL]-3,3-DIMETHYL-BUTANAMIDE'>01E</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wpo RCSB], [http://www.ebi.ac.uk/pdbsum/2wpo PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wpo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wpo RCSB], [http://www.ebi.ac.uk/pdbsum/2wpo PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VP40_HCMVA VP40_HCMVA]] Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein UL86 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein UL86. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assemblin is a protease essential for virion assembly in the nucleus. Catalyzes the cleavage of the assembly protein after complete capsid formation. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assembly protein plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein UL86. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 32: | Line 34: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human herpesvirus 5]] | [[Category: Human herpesvirus 5]] | ||
| - | [[Category: Deziel, R | + | [[Category: Deziel, R]] |
| - | [[Category: Lagace, L | + | [[Category: Lagace, L]] |
| - | [[Category: Massariol, M J | + | [[Category: Massariol, M J]] |
| - | [[Category: Qian, C | + | [[Category: Qian, C]] |
| - | [[Category: Tong, L | + | [[Category: Tong, L]] |
| - | [[Category: Yoakim, C | + | [[Category: Yoakim, C]] |
[[Category: Coat protein]] | [[Category: Coat protein]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Viral protease]] | [[Category: Viral protease]] | ||
Revision as of 18:18, 25 December 2014
HCMV protease inhibitor complex
| |||||||||||
