2p8v
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8V FirstGlance]. <br> | <table><tr><td colspan='2'>[[2p8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P8V FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HOMER3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p8v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p8v RCSB], [http://www.ebi.ac.uk/pdbsum/2p8v PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HOME3_HUMAN HOME3_HUMAN]] Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bouyain, S | + | [[Category: Bouyain, S]] |
| - | [[Category: Huang, G N | + | [[Category: Huang, G N]] |
| - | [[Category: Leahy, D | + | [[Category: Leahy, D]] |
| - | [[Category: Tu, J | + | [[Category: Tu, J]] |
| - | [[Category: Worley, P F | + | [[Category: Worley, P F]] |
[[Category: Evh1 domain]] | [[Category: Evh1 domain]] | ||
[[Category: Homer3]] | [[Category: Homer3]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 18:18, 25 December 2014
Crystal structure of human Homer3 EVH1 domain
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Categories: Homo sapiens | Bouyain, S | Huang, G N | Leahy, D | Tu, J | Worley, P F | Evh1 domain | Homer3 | Signaling protein
