3p8h
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p8h RCSB], [http://www.ebi.ac.uk/pdbsum/3p8h PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p8h RCSB], [http://www.ebi.ac.uk/pdbsum/3p8h PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LMBL1_HUMAN LMBL1_HUMAN]] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 18:24, 25 December 2014
Crystal structure of L3MBTL1 (MBT repeat) in complex with a nicotinamide antagonist
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Categories: Homo sapiens | Arrowsmith, C H | Bountra, C | Brown, P J | Edwards, A M | Frye, S V | Gao, C | Herold, J M | Kireev, D | Lam, R | Ouyang, H | Ravichandran, M | Structural genomic | Senisterra, G | Tempel, W | Vedadi, M | Weigelt, J | Mbt repeat | Methylated lysines on histone protein | Sgc | Transcription | Transcriptional repression
