2ayq

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2ayq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_coagulans Bacillus coagulans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ayq 1ayq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AYQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2ayq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_coagulans Bacillus coagulans]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ayq 1ayq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AYQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ayq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ayq RCSB], [http://www.ebi.ac.uk/pdbsum/2ayq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ayq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ayq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ayq RCSB], [http://www.ebi.ac.uk/pdbsum/2ayq PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LEU3_BACCO LEU3_BACCO]] Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.[HAMAP-Rule:MF_01033]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: 3-isopropylmalate dehydrogenase]]
[[Category: 3-isopropylmalate dehydrogenase]]
[[Category: Bacillus coagulans]]
[[Category: Bacillus coagulans]]
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[[Category: Takenaka, A.]]
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[[Category: Takenaka, A]]
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[[Category: Tsuchiya, D.]]
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[[Category: Tsuchiya, D]]
[[Category: Leucine biosynthesis]]
[[Category: Leucine biosynthesis]]
[[Category: Moderate thermophile]]
[[Category: Moderate thermophile]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]

Revision as of 18:27, 25 December 2014

3-ISOPROPYLMALATE DEHYDROGENASE FROM THE MODERATE FACULTATIVE THERMOPHILE, BACILLUS COAGULANS

2ayq, resolution 3.00Å

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