1hra
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1hra]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HRA FirstGlance]. <br> | <table><tr><td colspan='2'>[[1hra]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HRA FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hra OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hra RCSB], [http://www.ebi.ac.uk/pdbsum/1hra PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hra OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hra RCSB], [http://www.ebi.ac.uk/pdbsum/1hra PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RARB_HUMAN RARB_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.<ref>PMID:12554770</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 32: | Line 34: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Boelens, R | + | [[Category: Boelens, R]] |
| - | [[Category: Bonvin, A M.J J | + | [[Category: Bonvin, A M.J J]] |
| - | [[Category: Eib, D | + | [[Category: Eib, D]] |
| - | [[Category: Kaptein, R | + | [[Category: Kaptein, R]] |
| - | [[Category: Katahira, M | + | [[Category: Katahira, M]] |
| - | [[Category: Knegtel, R M.A | + | [[Category: Knegtel, R M.A]] |
| - | [[Category: Saag, P T.Van Der | + | [[Category: Saag, P T.Van Der]] |
| - | [[Category: Schilthuis, J G | + | [[Category: Schilthuis, J G]] |
[[Category: Dna-binding receptor]] | [[Category: Dna-binding receptor]] | ||
Revision as of 18:28, 25 December 2014
THE SOLUTION STRUCTURE OF THE HUMAN RETINOIC ACID RECEPTOR-BETA DNA-BINDING DOMAIN
| |||||||||||
