3lxu

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lxu RCSB], [http://www.ebi.ac.uk/pdbsum/3lxu PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lxu RCSB], [http://www.ebi.ac.uk/pdbsum/3lxu PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TPP2_DROME TPP2_DROME]] Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly-polypeptide.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 18:29, 25 December 2014

Crystal Structure of Tripeptidyl Peptidase 2 (TPP II)

3lxu, resolution 3.14Å

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